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Still, Robert Fleischer, a senior scientist for the Center for Conservation Genomics at the Smithsonian’s National Zoo & Conservation Institute in Washington, says that prospect is exciting.
“If I was a 12-year-old in my science class in junior high school I’d probably think this was pretty cool,” Fleischer says. “And I still think it’s pretty cool.”
The discovery of an ancient woolly mammoth: It’s funny to see how a genetically modified elephant might look, but it wouldn’t look like an elephant
“And that’s really exciting to be able to look at an extinct creature and be able to say, ‘Oh, yes. I can see this gene was on. The genes was on. The genes was off. Oh, isn’t that surprising?’” “I’m Aiden,” he says. “To be able to do all these specific things in a woolly mammoth is exciting.”
“The preservation of genetic architectures from the woolly mammoth is really remarkable,” Flessa says. It shouldn’t be done just because you can do it. A genetically modified Asian elephant is not a wooly mammoth. And releasing such an animal into the wild would be arrogant and irresponsible.”
And Karl Flessa, a professor of geosciences at the University of Arizona agrees on the scientific accomplishment and the foolishness of trying to bring back the extinct pachyderm.
“There’s an huge potential for unintended consequences,” Lynch says. Think about all the otherInvasive species that are in the world. You don’t really know the effect that species is going to have in the environment until it gets there.”
But Lynch isn’t a fan of trying to bring back the mammoth. The unintended consequences of that could be disastrous, he says. It would be better to spend the money on trying to save the elephants than on such a project.
An associate professor at the University at Buffalo who was not involved in the research thinks it’s pretty cool.
Challenging that assumption, Lieberman Aiden and his colleagues embarked on a nine-year-long search for well-preserved ancient samples, eventually finding nearly intact chromosomes in 52,000-year-old skin samples from a woolly mammoth (Mammuthus primigenius) unearthed from Siberian permafrost. Cynthia Pérez Estrada, a geneticist at the college, says the discovery was mind-blowing.
“Initially we had embarrassingly bad ideas. Aiden admitted toNPR that he was a little ashamed. “We said, ‘Oh, you know, that looks like a good-looking piece of mammoth on eBay. We should try that. It’s kind of a little cringe, right, to tell you that. It is a bad place to get samples.
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You would be able to see how the chromosomes were shaped in a living cell and you would also get a deeper understanding of ancient and extinct species and how those genomes worked.
“In biology, one of the most powerful tools for understanding the history of life on this planet is ancient DNA,” Aiden says. It’s an incredibly powerful tool for understanding the history of life
For years, scientists have been able to peer back in time by analyzing fragments of ancient DNA recovered from bones, fossilized teeth, mummies and even strands of hair.
“It’s exciting,” says Erez Lieberman Aiden, a professor of of molecular and human genetics and director of the Center for Genome Architecture at the Baylor College of Medicine in Houston. We think it will be very valuable.
The advance should provide important new insights into the biology of a creature that has long sparked fascination. Researchers and others said that the work could aid efforts to breed a living version of the animal.
The accomplishment, described Thursday in the journal Cell, marks what is believed to be the first time scientists have been able to produce a multidimensional version of the genome of a complex extinct species.
A study by the researchers has shown that the folding of the DNA and its location in the nucleus are very important in determining which genes are turned on and for how long.
The team’s experiments on freeze-dried beef jerky, which was subjected to extreme tests including being shot with a gun and run over with a car, confirmed the researchers’ theory: the jerky shattered like glass but its chromosomes remained intact.
Vctor Moreno Mayar, who was not involved in the study, says there’s no chance that ancient DNA stays in its current shape. Seeing that it can “is really cool”, he says.
The results suggest that it is possible to recover ancient DNA if the conditions are right.