Effects of aging on human blood stem cell populations and common lymphoma progenitors and common myeloid progenitor

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Weissman says that his team is working on a similar approach to rebalance aged human blood stem cells. It will be at least three to five years before they can begin testing it in people, despite ample funding.

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But it’s also possible that the antibody treatment did more than just affect the dominant blood stem cell population, says Enca Montecino-Rodriguez, who studies the development of white blood cells at the David Geffen School of Medicine at the University of California, Los Angeles. The treatment might also affect the environment in which the blood stem cells live. She says it could lead to the deletion of old cells in the body or cause an immune response that affects how the mice respond to vaccines and viruses.

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A group of people were involved in efficient transplantation via hematopoietic stem cell niches. Science had a paper published in 2007.

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Source: Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity

Neogenin-1 regulates substantia nigra development and promotes the formation of abdominal aneurysm in the human brain

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Source: Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity

Revitalization of Aging Immunity via Depleting Myeloid-Biased Hematopoietic Stem Cell Transplantation

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Source: Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity

WebGestalt 2019: An interactive web platform for analyzing gene expression data of human hematopoietic stem and progenitor cells

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Kleverov, M. et al. A web-application that allows for visual and interactive gene expression analysis. The print was published at bioRxiv which you can find at http://www.bio_rxiv.org.